Early Stage Investigator Grant: “Developing a Mouse Model of Pathological Gambling using an Inducible and Tissue-specific Serotonin 1B Receptor Knock-out”

Principal Investigator: Katherine Nautiyal, PhD, Columbia University and Research Foundation for Mental Hygiene, Inc.
Awarded $147,706 in 2013

Aim: Determine the role played by the serotonin 1B receptor in the development of impulsive behavior through a mouse gambling behavioral model.

Nautiyal, K.M., Tanaka, K.F., Barr, M.M., Tritschler, L., Le Dantec, Y., David, D.J., Gardier, A.M.,  Blanco, C., Hen, R., & Ahmari, S.E.(2015). Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity, Neuron 86 (3), 813-826. htttp://dx.doi.org/10.1016/j.neuron.2015.03.041.

Nautiyal, K., Wang, S., Wall, M., Ahmari, S., Balsam, P., Blanco, C., & Hen, R. (2015). Biological and Behavioral Dissection of the Role of the Serotonin 1B Receptor in Impulsivity. Neuropsychopharmacology, 40, pp. S305-S305

Year: 2013
Type: Project Grants