“Naltrexone and Citalopram Treatment of Pathological Gambling and Co-Morbid Alcohol Abuse or Dependence”

Principal Investigator: Marc N. Potenza, MD, Ph.D., Yale School of Medicine
Awarded $172,500 in 2000

Aim: Test the short-term tolerability and efficacy of the antidepressant citalopram, naltrexone (a drug used to blunt cravings for alcohol) and a citalopram/naltrexone combination pharmacotherapy in the treatment of dually diagnosed patients with pathological gambling and alcohol abuse or dependence.

Potenza, M.N. (2001). The neurobiology of pathological gambling. Seminars in Clinical Neuropsychiatry, 6, 217-226.

Potenza, M.N. (2001). Pathological gambling: A present problem from the past. Psychiatric Times (online exclusive).

Potenza, M.N. (2002). A perspective on future directions in the prevention, treatment, and research of pathological gambling. Psychiatric Annals, 32, 203-207.

Potenza, M.N. (2003). Pathological gambling and impulse control disorders. In J. Soares & S. Gershon (Eds.), Medical Handbook of Psychiatry, pp. 683-700.

Potenza, M. N. (2005). Advancing Treatment Strategies for Pathological Gambling.
Journal of Gambling Studies, 21(1), 91-98.

Potenza, M.N. & Charney, D.S. (2001). Pathological gambling: A current perspective. Seminars in Clinical Neuropsychiatry, 6, 153-154.

Potenza, M.N., Fiellin, D. A., Heninger, G.R., Rounsaville, B.J., & Mazure, C.M. (2002). Gambling: An addictive behavior with health and primary care implications. Journal of General Internal Medicine, 17, 721-32.

Potenza, M.N. & Hollander, E. (2002). Pathological gambling and impulse control disorders. In C. Nemeroff, J. Coyle, D. Charney, & K. Davis (Eds.), Neuropsychopharmacology: The 5th Generation of Progress. Baltimore, MD: Lippincott, Williams and Wilkens.

Potenza, M.N., Kosten, T.R., & Rounsaville, B.J. (2001). Pathological gambling. Journal of the American Medical Association, 286, 141-144.

Potenza, M.N., Leung, H.C., Blumberg, H.P., Peterson, B.S., Fulbright, R.K., Lacadie, C.M., et al. (2003). An fMRI Stroop study of ventromedial prefrontal cortical function in pathological gamblers. American Journal of Psychiatry, 160, 1990-1994.

Potenza, M.N., Steinberg, M.A., Skudlarski, P., Fulbright, R.K., Lacadie, C.M., Wilber, M.K., et al. (2003). An fMRI study of gambling urges in pathological gamblers. Archives of General Psychiatry, 60(8), 828-836.

Potenza, M.N. & Wilber, M.K. (2001). Neuroimaging studies of pathological gambling and substance dependence. Psychiatric Times, 18(10): 58-64.

Potenza, M.N. & Winters, K.C. (2003). The neurobiology of pathological gambling: Translating research findings into clinical advances. Journal of Gambling Studies, 19, 7-10.

Chambers R. A., & Potenza, M.N., (2003). Impulse control disorders. In M.J. Aminoff & R.B. Daroff (Eds.), Encyclopedia of the Neurological Sciences (Vol. 2). San Diego, CA:  Academic Press.

Chambers, R. A. & Potenza, M.N., (2003). Neurodevelopment, impulsivity and adolescent gambling. Journal of Gambling Studies, 19, 53-84.

Chambers, R. A., Taylor, J.R. & Potenza, M.N. (2003). Developmental neurocircuitry of motivation in adolescence: A critical period of addiction vulnerability. American Journal of Psychiatry, 160, 1041-1052.

Grant, J.E., Kim, S.W., & Potenza, M.N. (2003). Advances in the pharmacological treatment of pathological gambling. Journal of Gambling Studies, 19, 85-109.

Grant, J. E., Kim, S.W., Potenza, M.N., Blanco, C., Ibanez, A., Stevens, L., et al. (2003). Paroxetine treatment of pathological gambling: A multi-centre randomized controlled trial. International Clinical Psychopharmacology, 18, 243-249.

Grant, J.E., & Potenza, M.N. (Eds). (2004). Pathological gambling: A clinical guide to treatment. Washington, DC:  American Psychiatric Press, Inc.

Shah, K.R., Eisen, S.A., Xian, H., Potenza, M.N. (2005). Genetic studies of pathological gambling: A review of methodology and analyses of data from the Vietnam Era Twin (VET) Registry. Journal of Gambling Studies, 21(2), 179-203.

Year: 2000
Type: Project Grants