Principal Investigator: Charan Ranganath, Ph.D., University of California-Davis
Awarded $170,291 in 2003

Aim: Test hypothesis that low extraversion scores and reduced dopamine levels predispose some to develop a gambling problem.

Cohen, M. X., & Ranganath, C. (2005). Behavioral and neural predictors of upcoming decisions. Cognitive, Affective and Behavioral Neuroscience, 5(2), 117–26.

Cohen, M. X., Young, J., Baek, J. M., Kessler, C., & Ranganath, C. (2005). Individual differences in extraversion and dopamine genetics predict neural reward responses. Cognitive Brain Research, 25(3), 851–861.

Ranganath, C., & Blumenfeld, R. S. (2005). Doubts about double dissociations between short- and long-term memory. Trends in Cognitive Science, 9(8), 374–80.

Ranganath, C. (2006). Working memory for visual objects: complementary roles of inferior temporal, medial temporal, and prefrontal cortex. Neuroscience, 139(1), 277–89. [pii] 10.1016/j.neuroscience.2005.06.092

Ranganath, C., Cohen, M. X., & Brozinsky, C. J. (2005). Working memory maintenance contributes to long-term memory formation: neural and behavioral evidence. Journal of Cognitive Neuroscience, 17(7), 994–1010.

Principal Investigator: Jody Tanabe, MD, University of Colorado Health Sciences Center
Awarded $172,500 in 2003

Aim: Test hypothesis that defects in ventral medial frontal processing lead to impaired decisions that involve risk.

Tanabe, J., Thompson, L., Claus, E., Dalwani, M., Hutchison, K., & Banich, M. T. (2007). Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision-making. Human Brain Mapping, 28(12), 1276–86.

Tanabe, J., Tregellas, J. R., Thompson, L., Dalwani, M., Owens, E., Crowley, T., & Banich, M. (2009). Medial orbitofrontal cortex gray matter is reduced in abstinent substance dependent individuals. Biological Psychiatry, 65(2), 160–164.

Principal Investigator: Alain Dagher, MD, McGill University
Awarded $156,634 in 2003

Aim: Examine whether reduced dopamine levels is a marker for vulnerability to gambling addiction. The hypothesis is that compared to controls, pathological gamblers will show elevated dopamine release correlates with novelty-seeking personality type, cortisol levels and autonomic and mood measures.

Faculty Member at the George Warren Brown School of Social Work

Associate Professor of Psychiatry
Director, Problem Gambling Clinic
Yale University School of Medicine