The relationship between the brain chemical dopamine and disordered gambling has been well-established over the past several years (we discussed this relationship in the context of Parkinson's Disease in the July 2010 Issues and Insights). Dopamine is associated with the reward system of the brain, which affects feelings of enjoyment and behavior reinforcement. It and other brain chemicals are, by their very nature, difficult to observe and thus difficult to translate into preventive applications. To bridge the gap between brain chemistry and disordered behavior, researchers can link the two with quantifiable emotions like excitement. The most recent edition of The WAGER (Worldwide Addiction Gambling Education Report) reviews a study that looks at those factors as they relate to pathological gambling.