Principal Investigator: Jessica Caballero, University of Massachusetts Amherst
Awarded $ 2,000 in 2019
Aim: Abnormal control of execution and inhibition of behaviors is a major contributor to problems like gambling and addiction. People that have problems controlling the execution and inhibition of behaviors are often impulsive and constantly seek the reward they are after. The prelimbic (PL) and the infralimbic (IL) subregions of the medial prefrontal cortex (mPFC), and their projections to the nucleus accumbens core (NACc) and sell (NACsh) have been strongly implicated in the behavioral execution/inhibition balance. The aims of this animal study are: 1) Determine PL and IL influence over response execution and inhibition; and 2) determine circuitry mediating the execution and inhibition of reward seeking behaviors.