Archive for category: Project Grants

Principal Investigator: Suck Won Kim, MD, University of Minnesota Medical School
Awarded $53,374 in 1998

Aim: Test efficacy of naltrexone, a drug used to blunt cravings for alcohol, for treating pathological gambling. In 2002, the lead investigator was awarded $464,463 by the National Institute of Mental Health to expand this study.

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Kim, S.W. & Grant, J.E. (2001). An open naltrexone treatment study in pathological gambling disorder. International Clinical Psychopharmacology, 16, 285-289.

Kim, S.W. & Grant, J.E. (2001). The psychopharmacology of pathological gambling. Seminars in Clinical Neuropsychiatry, 6, 184-194.

Kim, S.W., Grant, J.E. & Adson, D.E. (2001). Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling. Biological Psychiatry, 49, 914-921

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Principal Investigator: Hans Breiter, MD, Massachusetts General Hospital
Awarded $172,500 in 1999

Aim: Understand brain activation produced by a monetary reward in a gambling-like experiment. As a result of this grant support, the lead investigator received support from National Institutes of Health and the Office of National Drug Control Policy.

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Aharon, I., Etcoff, N., Ariely, D., Chabris, C. F., O’Connor, E., & Breiter, H. C. (2001). Beautiful faces have variable reward value: fMRI and behavioral evidence. Neuron, 32(3), 537-551.

Breiter, H. C., Aharon, I., Kahneman, D., Dale, A. & Shizgal, P. (2001). Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron, 30, 619-639.

Breiter, H., & Gasic, G. P. (2004). A general circuitry processing reward/aversion information and its implications for neuropsychiatric illness. In M. Gazzaniga (Ed.), The Cognitive Neurosciences, III (3rd ed., pp. 1043-1065). Cambridge: MIT Press.

Makris, N., Gasic, G.P., Seidman, L.J., Goldstein, J.M., Gastfriend, D.R., Elman, I., Albaugh, M.D., Hodge, S.M., Ziegler, D.A., Sheahan, F.S., Caviness, V.S., Tsuang, M.T., Kennedy, D.N., Hyman, S.E., Rosen, B.R., Breiter, H.C. (2004). Decreased absolute amygdala volume in cocaine addicts. Neuron, 4(4), 729-40.

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Principal Investigator: Lawrence E. Jones, Ph.D., University of Illinois at Urbana-Champaign
Awarded $172,155 in 1999

Aim: Identify and describe several distinct “types” of gambling styles and strategies, including ones that will distinguish between subtypes of pathological gamblers.

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Principal Investigator: Jennifer Langhinrichsen-Rohling, Ph.D., University of South Alabama
Awarded $125,800 in 1999

Aim: Understand the role of demographic, individual, family, and peer variables in the development of gambling problems among adolescents.

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Langhinrichsen-Rohling, J. (2004). The associations among gambling, depression, and suicidal behavior in adolescents. In J. Derevensky and R. Gupta (Eds.), Gambling Problems in Youth: Theoretical and Applied Perspectives. New York: Kluwer Academic/Plenum Publishers.

Langhinrichsen-Rohling, J., Rohde, P., Seeley, J. R., & Rohling, M. L. (2004). Individual, family, and peer correlates of adolescent gambling. Journal of Gambling Studies, 20, 23-46.

Langhinrichsen-Rohling, J., Rohling, M. L., Rohde, P., & Seeley, J. R. (2004). The SOGS-RA versus the MAGS-7: Prevalence estimates and classification congruence. Journal of Gambling Studies, 20, 259-281.

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Principal Investigator: Marc N. Potenza, MD, Ph.D., Yale School of Medicine
Awarded $172,500 in 2000

Aim: Test the short-term tolerability and efficacy of the antidepressant citalopram, naltrexone (a drug used to blunt cravings for alcohol) and a citalopram/naltrexone combination pharmacotherapy in the treatment of dually diagnosed patients with pathological gambling and alcohol abuse or dependence.

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Potenza, M.N. (2001). The neurobiology of pathological gambling. Seminars in Clinical Neuropsychiatry, 6, 217-226.

Potenza, M.N. (2001). Pathological gambling: A present problem from the past. Psychiatric Times (online exclusive).

Potenza, M.N. (2002). A perspective on future directions in the prevention, treatment, and research of pathological gambling. Psychiatric Annals, 32, 203-207.

Potenza, M.N. (2003). Pathological gambling and impulse control disorders. In J. Soares & S. Gershon (Eds.), Medical Handbook of Psychiatry, pp. 683-700.

Potenza, M. N. (2005). Advancing Treatment Strategies for Pathological Gambling.
Journal of Gambling Studies, 21(1), 91-98.

Potenza, M.N. & Charney, D.S. (2001). Pathological gambling: A current perspective. Seminars in Clinical Neuropsychiatry, 6, 153-154.

Potenza, M.N., Fiellin, D. A., Heninger, G.R., Rounsaville, B.J., & Mazure, C.M. (2002). Gambling: An addictive behavior with health and primary care implications. Journal of General Internal Medicine, 17, 721-32.

Potenza, M.N. & Hollander, E. (2002). Pathological gambling and impulse control disorders. In C. Nemeroff, J. Coyle, D. Charney, & K. Davis (Eds.), Neuropsychopharmacology: The 5th Generation of Progress. Baltimore, MD: Lippincott, Williams and Wilkens.

Potenza, M.N., Kosten, T.R., & Rounsaville, B.J. (2001). Pathological gambling. Journal of the American Medical Association, 286, 141-144.

Potenza, M.N., Leung, H.C., Blumberg, H.P., Peterson, B.S., Fulbright, R.K., Lacadie, C.M., et al. (2003). An fMRI Stroop study of ventromedial prefrontal cortical function in pathological gamblers. American Journal of Psychiatry, 160, 1990-1994.

Potenza, M.N., Steinberg, M.A., Skudlarski, P., Fulbright, R.K., Lacadie, C.M., Wilber, M.K., et al. (2003). An fMRI study of gambling urges in pathological gamblers. Archives of General Psychiatry, 60(8), 828-836.

Potenza, M.N. & Wilber, M.K. (2001). Neuroimaging studies of pathological gambling and substance dependence. Psychiatric Times, 18(10): 58-64.

Potenza, M.N. & Winters, K.C. (2003). The neurobiology of pathological gambling: Translating research findings into clinical advances. Journal of Gambling Studies, 19, 7-10.

Chambers R. A., & Potenza, M.N., (2003). Impulse control disorders. In M.J. Aminoff & R.B. Daroff (Eds.), Encyclopedia of the Neurological Sciences (Vol. 2). San Diego, CA:  Academic Press.

Chambers, R. A. & Potenza, M.N., (2003). Neurodevelopment, impulsivity and adolescent gambling. Journal of Gambling Studies, 19, 53-84.

Chambers, R. A., Taylor, J.R. & Potenza, M.N. (2003). Developmental neurocircuitry of motivation in adolescence: A critical period of addiction vulnerability. American Journal of Psychiatry, 160, 1041-1052.

Grant, J.E., Kim, S.W., & Potenza, M.N. (2003). Advances in the pharmacological treatment of pathological gambling. Journal of Gambling Studies, 19, 85-109.

Grant, J. E., Kim, S.W., Potenza, M.N., Blanco, C., Ibanez, A., Stevens, L., et al. (2003). Paroxetine treatment of pathological gambling: A multi-centre randomized controlled trial. International Clinical Psychopharmacology, 18, 243-249.

Grant, J.E., & Potenza, M.N. (Eds). (2004). Pathological gambling: A clinical guide to treatment. Washington, DC:  American Psychiatric Press, Inc.

Shah, K.R., Eisen, S.A., Xian, H., Potenza, M.N. (2005). Genetic studies of pathological gambling: A review of methodology and analyses of data from the Vietnam Era Twin (VET) Registry. Journal of Gambling Studies, 21(2), 179-203.

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