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Principal Investigator: Serena M. King, Ph.D., L.P., Hamline University
Awarded $57,318 in 2009
Aim: Understand the roles that behavioral problems, genes and environment play in gambling behaviors from adolescence to young adulthood.
Principal Investigator: Adam Goodie, PhD, University of Georgia
Awarded $172,233 in 2009
Aim: Determine if certain personality types have a direct, causal link to pathological gambling in order to inform prevention and treatment for different kinds of disordered gamblers.
Associate Professor of Psychiatry
University of Minnesota Medical School
Co-Director, Impulse Control Disorders Clinic
University of Minnesota Medical Center
Principal Investigator: Marc N. Potenza, M.D., Ph.D.
Award: $402,500 in 2009
“The Yale Gambling CORE (Center Of Research Excellence)” is building upon existing collaborations and interdisciplinary of the PI and his research team, including the Women’s Health Research at Yale, the VA VISN 1 MIRECC (focusing on co-occurring disorders), Yale Child Study Center, Yale Center for Translational Neuroscience in Alcoholism, Yale Psychotherapy Development Center, and multiple training programs. Collaborations outside of Yale will include the Connecticut Council on Problem Gambling, Problem Gambling Services, the National Council on Problem Gambling, and the National Center for Responsible Gaming. The main research component is a study that involves the disciplines of treatment development, brain imaging, molecular genetics and behavioral/neurocognitive assessment and is investigating factors associated with outcome in pathological gambling treatment.
Principal Investigator: Jon E. Grant, JD, MD, M.P.H.
Award: $402,500 in 2009
Emerging evidence shows remarkable similarities in signs, symptoms, and neuro-pathology among several forms of impulsive behavior, such as pathological gambling, excessive drug and alcohol use, and risk taking behaviors such as driving recklessly and sexual promiscuity. Recent clinical and preclinical studies indicate that severity of impulsivity reflects varying degrees of control over motivational neurocircuitry and may provide the key to understanding the core pathology underlying these ostensibly distinct disorders. More specifically, identifying and understanding these commonalities of impulsivity, as well as the varying degrees of impulse inhibition, may reveal the driving force underlying pathological gambling.
The overall goal of this Center is to expand upon these important initial preclinical and clinical studies by implementing a translational approach in an interdisciplinary team that uses information from young adults with a range of impulsive behaviors to examine underlying neuropsychological and cognitive mechanisms that lead to the vulnerability, development and treatment of pathological gambling. The behaviors that characterize pathological gambling (e.g., chasing losses, preoccupation with gambling, inability to stop) have been strongly linked to an inability to inhibit reward-seeking, also referred to as “impulsivity” or “disinhibition”. Developmentally, impulsive behavior that underlies pathological gambling tends to start during late adolescence or early adulthood. Recent theoretical work has suggested that impulsivity may arise as a coherent construct arising from multiple perspectives, including neuroeconomic, cognitive, and neuropsychological perspectives. Relatively little research, however, has focused on incorporating these multiple perspectives into a coherent understanding of impulsivity and pathological gambling. This Center proposes to integrate research in the fields of cognition, neuroeconomics, and computational modeling to develop and validate a susceptibility detection model of impulsivity. This model of impulsivity will allow for the early detection of susceptible youth and, with early treatment interventions, will prove that progression to pathological gambling, and perhaps other disorders of impulse control, can be prevented.
